生物硫醇包括Cys,Hcy和GSH在生物体系中广泛存在,参与多项生命活动.因此,跟踪检测生物硫醇在生物学研究方面意义重大.本组合成了若干中喹啉-2-甲撑丙二酸(QMA)及其酯衍生物,研究了它们作为荧光探针在巯基检测及细胞成像上的应用.对于一般的巯基荧光探针,在酸性条件下不能与巯基化合物发生迈克尔加成反应,只有在碱性条件下,巯基亲核活性得到增强,才能发生反应.
Cross-dehydrogenative-coupling (CDC) reaction has long been recognized as a powerful tool to form a C-C bond directly from two different C-H bonds.This reaction is particularly attractive because it a
The direct conversion of sunlight into chemical energy in the form of hydrogen (H2) is the best solutions for energy crisis and environmental pollution.[1] To design an artificial photocatalyst that i
Solar energy conversion of water into clean fuel hydrogen (H2) offers one of the best solutions for meeting future energy demands.Natural [FeFe]-hydrogenase ([FeFe]-H2ase) is known to catalyze the rev
Catalytic functionalization of amines by direct C-H activation has attracted much attention in organic chemistry in recent years, because functionalized amines are versatile intermediates and have bee
Photochemical reaction of cyclohexyl phenyl ketone (1) leads either to intra-or intermolecular hydrogen abstraction product (2 and 3 respectively), and 3 consists of pair of enantiomers.Two types of c
To make "clean" reduced GO sheets in high quality and in large scale, a natural reduced nicotinamine adenine dinucleotide NAD(P)H model, Hantzsch 1,4-dihydropyridine (HEH), is used as a mild organic r
Thanks to superior redox potential of platinum(Ⅱ) complex 1 to that of Ru(bpy)32+ in the excited state,[1] an efficient and selective visible-light-induced CDC reaction[2] has been developed by using
[FeFe]-hydrogenase, a kind of microbial enzyme featuring hydrogen metabolism, has remarkable catalytic efficiency in proton reduction.The study of photocatalytic hydrogen production based on [FeFe]-hy
Gold-catalyzed intramolecular oxidation of terminal alkynes with arenesulfinyl group as the tethered oxidant is an important reaction in gold chemistry, and introduced to the field the highly valued c