【摘 要】
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It is increasingly accepted that enzyme promiscuity is not a rare phenomenon; rather,it appears to be widespread and may even be an inherent feature in the
【机 构】
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ChineseAcademyofMedicalSciencescfePekingUnionMedicalCollege,IXianNongTernStreet,Beijing100050,P.R,Ch
【出 处】
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活性天然产物生物合成及合成生物学学术论坛
论文部分内容阅读
It is increasingly accepted that enzyme promiscuity is not a rare phenomenon; rather,it appears to be widespread and may even be an inherent feature in the biology.The promiscuous enzymes are highly valuable in many synthetic applications,ranging from the laboratory to industry,especially in reactions that are difficult to access by chemical methods such as carbon-carbon bond formation and ring system construction.Therefore,there is a large drive to discover or develop universal enzymes that can be used for general chemical syntheses and drug discovery.In the present speech,the enzyme promiscuity of novel glycosyltransferases and prenyltransferases and their application in diversity-oriented structural innovation and drug discovery are introduced.In particular,the molecular mechanisms of enzyme promiscuity of a novel aromatic prenyltransferase,AtaPT,and structure-guided mutagenesis for altering the specificity and promiscuity,will be discussed.
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