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The supercritical CO2 drying is a new drying technique, which just begins in the utilization of food processing.In order to master the supercritical CO2 drying character of tilapia fillet, the influences of the temperature, pressure and CO2 flow on supercritical CO2 drying process of tilapia fillet under certain condition were studied and the equations of drying curve were fitted.The results showed that drying temperature had a significant effect on supercritical CO2 drying process, while pressure and flow of CO2 had a less effect on supercritical CO2 drying.