【摘 要】
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Porcine reproductive and respiratory syndrome virus (PRRSV) infection results in extensive tissue inflammation and damage,which are believed to be responsible for increased susceptibility to secondary
【机 构】
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Laboratory of Molecular Virology and Immunology, College of Veterinary Medicine, Agricultural Univer
【出 处】
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2013国际猪繁殖与呼吸综合征学术研讨会
论文部分内容阅读
Porcine reproductive and respiratory syndrome virus (PRRSV) infection results in extensive tissue inflammation and damage,which are believed to be responsible for increased susceptibility to secondary infection and even for death.However,its pathogenic mechanisms are not fully understood.To explore the mechanism underlying the PRRSV-induced tissue inflammation and damage,we investigated whether PRRSV activates porcine alveolar macrophage (PAM) inflammasomes which mediate por-IL-1β maturation/release and subsequently induce tissue inflammation and injury.Our results showed that PRRSV and its small envelope protein E significantly increased IL-1β release from LPS-primed macrophages,however,only PRRSV not protein E significantly increased IL-1β release from no-LPS-primed PAMs,which indicates that PRRSV can activate inflammasomes of PAMs by its encoded protein E.These results provide a molecular basis for the pathogenic mechanism of PRRSV on inducing extensive tissue inflammation and damage,and suggest that the inflammasome may provide a potential therapeutic target for PRRS prevention and treatment.
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