Molecular mechanism of regulation of extramedullary infiltration by APP gene in AML1/ETO positive ac

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Amyloid precusor protein (APP) has been reported to be highly expressed in AML1/ETO positive acute myeloid leukemia (AML1/ETO+ AML),and we found it express even higher in those with extramedullary infiltration in our previous study.Yet,its still unknown what role APP plays and how it works in AML1/ETO+ AML.
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