论文部分内容阅读
Drug discovery is slow and extremely expensive that resulting in low rates of novel agents entering the clinic.One approach to solve this problem is to develop a better understanding of the fragment-based drug design of old drugs.The difference changes in metabolite concentrations can sensitive reflect the genomic changes and responses of cells and tissues to extemal stimuli.Consequently, the development of powerful metabolomic platforms will greatly helpful to understand the actions of drugs and aid them reaching the clinic.