【摘 要】
：
BackgroundInositol 1,4,5-trisphosphate receptor (IP3R) is abundant in the vascular smooth muscle cells "SMCs" and IP3R form tetrameric channels in endoplasmic reticulum membranes that conduct Ca2+ in
【机 构】
：
Department of Cardiology, People's Hospital, Peking University Beijing 100044, P.R., China
【出 处】
：
2005 World DNA and Genome Day(2005中国(大连)国际DNA和基因组节大会)
论文部分内容阅读
BackgroundInositol 1,4,5-trisphosphate receptor (IP3R) is abundant in the vascular smooth muscle cells "SMCs" and IP3R form tetrameric channels in endoplasmic reticulum membranes that conduct Ca2+ in an Inositol 1,4,5-trisphosphate (IP3)-sensitive manner.IP3-mediated Ca2+ release is regulated by [Ca2+]i,with positive and negative feedback acting in a bell-shaped manner with peak Ca2+ release activity at 300 nM Ca2+.Nitric oxide (NO) is a negative regulator of vascular SMC proliferation,which its antiproliferative effect is mediated via guanosine-3,5-cyclic monophosphate (cGMP) and cGMP dependent protein kinase (PKG).
其他文献
This study was conducted to determine the effect of dietary supplementation of vitamin E supplements on non-specific immunity immune responses in juvenile soft-shelled turtles.The Tsoft-shelled turtle
Our research interests are focusing on the genes involved in the development of germ cells.One of our works was about the germ-cell-deficient (gcd) mutant,a sterile mutant resulted from the reduced nu
Protection of our water resources is one of the most significant environmental challenges of the new millennium.Fecal pollution is a serious environmental problem that affects many coastal regions in
The Spodoptera litura nucleopolyhedrovirus (SpltNPV) gp37 fusion gene was inserted into the transfer vector (pBacPAK9),named pBacPAKSL37fus.The vector was cotransfected BT 1-Tn5B 1-4 (Hi5) cells with
Research of the protein composition of different parts of the middle silk gland (MSG) cells of the fifth instar larvae of silkworm (Bombyx mori L.) are useful to frnd the functional protein concemed w
Background:Polymorphism of HIV co-receptor,CC chemokine receptor 5 (CCRS),varies with geographical location and may potentially affect HIV-1 infection and disease progression.Method:Two groups of Chin
PCR-RFLP technique was applied to distinguish mitten crab samples.The around 1600bp fragments of mitochondrial 12s-16s rDNA of mitten crab from ten areas in China (E.sinensis and E.japonicahepuensis)
To investigate genome size evolution,it is usually informative to compare closely related species that vary dramatically in genome size.A whole genome duplication (polyploidy) occurred in rice (Oryza
Objective:To study the mechanism of invasion and metastasis in mucinous carcinoma (MC) of breast,stomach and large intestine,by observing the character of their mucins,the expression of nm23-H 1,CD44V
Aim:N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS398),is a highly selective-2 inhibitor.It is not only used in the anti-inflammation,but more and more studies are dedicated to the researc