【摘 要】
:
Animal models of oncology are often viewed in the industry setting as being historically nonpredictive of clinical outcome.However, we must ask ourselves whether we are posing the correct questions wi
【机 构】
:
EMD Serono Research & Development Institute USA
论文部分内容阅读
Animal models of oncology are often viewed in the industry setting as being historically nonpredictive of clinical outcome.However, we must ask ourselves whether we are posing the correct questions with our models and properly interpreting the data when using them for making decisions.
其他文献
CD147 protein is encoded by BSG (basigin) gene, also is known as EMMPRIN.CD147 is a membrane protein, primarily localizes on cytoplasmic membrane, and elevated in multiple kinds of cancer tissues, inc
食管癌是人类常见的消化道恶性肿瘤,在世界范围内其发病率位居所有肿瘤的第八位,死亡率位居所有肿瘤的第六位。大量流行病学调查表明,在一些食管癌高发区居民粮食中伏马菌素B1 (FB1)的污染水平明显高于低发区,而营养因素在食管癌的发生中也起到重要作用。本研究在江苏淮安食管癌高发区收集由县级以上人民医院提供的2007年至2009年经X线、内窥镜或病理确诊的未化疗食管鳞状细胞癌手术病例152例,开展伏马菌素
目前,恶性肿瘤依然是威胁人类生命健康最主要的疾病之一,是全世界面临的严重公共卫生问题。对肿瘤发生发展机制的探讨是肿瘤转化医学研究的基础,将为肿瘤的早期诊断、个体化治疗、预后判断和预防等提供有价值的科学依据。本研究围绕新的环境应答基因JWA与肿瘤发生发展关系,采用系列细胞和分子生物学技术和模型、动物模型以及人群研究,探讨了JWA基因在应答氧化应激所致的DNA损伤修复、肿瘤发生、肿瘤转移等关键环节中的
EZH2, as a histone H3K27 methyltransferase, plays an essential role in regulation of cell proliferation,survival, invasiveness and cancer stem cell (CSC) maintenance.The upregulation of the histone me
Cytotoxic cancer chemotherapeutic agents continue to play an important role in the treatment of cancer.However, dose-limiting toxicities limit their use and efficacy.Nanomedicne could play an importan
Constant overexpression and activity of various cell signaling proteins, such as signal transducer and activator of transcription 3 (STAT3) and serine-threonine protein kinase AKT proteins, as well as
Metallo-supramolecular chemistry has been used to generate cationic supramolecular helicates possessing promising anticancer and antimicrobial activity.It has been hypothesized that binding to DNA is
PIK3家族包括Ⅰ、Ⅱ、Ⅲ型.这个家族的基因在肿瘤中的生物学功能有很大差异.常见的PIK3CA在结直肠癌中呈现拷贝数扩增,是典型的癌基因;但是,这个家族另外的成员PIK3CG在结直肠癌发生中却呈现拷贝数缺失,被认为是一个抑癌基因.PIK3C2G,属于Ⅱ型PIK3基因.目前的研究表明它在慢性粒性白血病发病过程中被Bcr-Abl抑制,表达量显著降低,提示它在慢性粒性白血病发病过程中起抑制作用.
世界范围,癌症是继心血管之后的第二位导致人类死亡的因素。据我国2000年卫生事业发展情况统计公报,城市地区居民死因第一位为恶性肿瘤。目前,还没有有效手段来治疗癌症,特别是对晚期癌症患者的治疗,传统的治疗方法就是手术切除、放射性治疗和化学治疗。癌症的免疫治疗,是一种新兴的、具有显著疗效的肿瘤治疗模式,是继手术、放疗和化疗之后的第四大肿瘤治疗技术。
褪黑素,松果体的主要分泌产物,对多种肿瘤有抗肿瘤活性.然而,褪黑激素的作用的分子机制尚不清楚.Sirt1是存在于哺乳动物的酵母染色质沉默子Sirt2同源体,是一种依赖NAD+的组蛋白去乙酰化酶,在肿瘤细胞中,Sirt1的表达或功能异常是肿瘤发生发展的重要机制之一,并可能成为治疗肿瘤的潜在靶点.在这项研究中,我们评估了褪黑素对人骨肉瘤细胞(9607细胞系)的抗肿瘤活性,并探讨SIRT1在褪黑素发挥活