【摘 要】
：
本研究采用生物信息学和分子生物学结合的方法,发现和鉴定人类基因组中肿瘤相关的反式作用小干扰RNA (tasiRNA)基因同系物.在完成人类基因组,MPSS和小RNA数据的采集和预处理
【出 处】
：
第五届中国小核酸技术与应用学术会议
论文部分内容阅读
本研究采用生物信息学和分子生物学结合的方法,发现和鉴定人类基因组中肿瘤相关的反式作用小干扰RNA (tasiRNA)基因同系物.在完成人类基因组,MPSS和小RNA数据的采集和预处理工作的基础上,设计和实现tasiRNA基因识别算法,基于测序分析的数据重新筛选候选基因,并基本的分子生物学验证.本研究在参考已有其他物种小RNA种类的基础上,发现人类基因组新类型的肿瘤相关tasiRNA,并开发相应的具有可扩展性的技术体系.
其他文献
Currently,major concerns about the safety and efficacy of RNA interference (RNAi)-based bone anabolic strategies still exist because of the lack of direct osteo
Intermittent oxygen deficiency in cancers promotes prolonged inflammation,continuous angiogenesis,and increased drug resistance.Hypoxia inducible factor-1 (HIF1
Despite small interfering RNA (siRNA) has garnered much interest as a potential drug for various diseases,the clinical application of siRNA still faces consider
2008年以来,依托以昆山小核酸研究所为核心,昆山构建小核酸产业技术创新平台,聚集专业服务和要素资源,奠定昆山小核酸产业发展的基础.面临全球小核酸技术产业化的关键节点,在
The application of nanotechnology to engineer nanovectors for siRNA delivery is widely expected to bring breakthrough in nanomedicine and create entirely novel
The most remarkable findings in the past two decades in biology include how the mammalian genome is largely transcribed and how versatile functions RNA molecule
Chromatin remodeling is an essential event for HIV-1 transcription.The HIV-1 transactivator,Tat,plays a major role in assembling a number of required transcript
The CRISPR RNA-guided Cas9 nuclease gene-targeting system has been successfully used for genome editing in a variety of organisms.Here,we report the use of
The application of nanotechnology for drug delivery is widely expected to bring promise and create novel therapeutics.[1] Particularly exciting are the recent e
Hydrogen sulfide(H2S)is an important endogenous signalling molecule with multibiological functions.Studies have shown that H2S level is correlated with nume