【摘 要】
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Objectives: To assess the efficacy and safety of a novel cell therapy for mate stress urinary incontinence consisting ofperiurethral injection ofautologous adipose-derived regenerative cells, and to d
【机 构】
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Nagoya University Japan
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Objectives: To assess the efficacy and safety of a novel cell therapy for mate stress urinary incontinence consisting ofperiurethral injection ofautologous adipose-derived regenerative cells, and to determine the 1-year outcomes.Methods: Eleven male patients with persistent stress urinary incontinence after prostate surgery were included in the study.The CelutionTM system was used to isolate adipose-derived regenerative cells from abdominal adipose tissue obtained by liposuction.Subsequently, these regenerative cells and a mixture of regenerative cells and adipose tissue were transurethrally injected into the rhabdosphincter and submucosal space of the urethra, respectively.One-year outcomes were assessed using a 24-hour pad test, a validated patient questionnaire, urethral pressure profile, transrectal ultrasonography, and magnetic resonance imaging.Results: Stress urinary incontinence improved progressively in 8 patients during the 1-year followup, as determined by a 59.8% decrease in the leakage volume in the 24-hour pad test, decreased frequency and amount of incontinence, and improved quality of life.One patient achieved total continence.Mean maximum urethral closing pressure and functional profile length increased from 35.5 to 44.7 cmH2O and from 20.4 to 26.0mm, respectively.Magnetic resonance imaging showed the sustained presence of the injected adipose tissue, and enhanced ultrasonography demonstrated a progressive increase in blood flow to the injected area in all patients.No significant adverse events were observed peri-or postoperatively.Conclusion: The results of this preliminary study showed that periurethral injection of autologous adipose-derived regenerative cells is a safe and feasible novel treatment modality for male stress urinary incontinence.
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