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Novel bio-inspired nanovector of alkaline amino acids such as arginine- (Arg),histidine- (His),and lysine- (Lys) based dendritic liposomes (BNVs) are developed to simulate the components of viral envelopes to enhance transfection efficiency.The cationic assemblies formed from lysine- or arginine-type lipids gave suitable unilamellar vesicles condensed pDNA,whereas the DNA binding ability of the histidine-type lipids was poor for application.