【摘 要】
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OBJECTIVE: Both estrogen receptors, ER alpha (ERα) and ER beta (ERβ), are expressed in 50-70% of breast cancer tissue.The role of ERα as a prognostic mar
【机 构】
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BeijingMunicipalKeyLaboratoryofClinicalEpidemiology,SchoolofPublicHealth,CapitalMedicalUniversity,Be
【出 处】
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首都医科大学公共卫生学院第五届学术年会
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OBJECTIVE: Both estrogen receptors, ER alpha (ERα) and ER beta (ERβ), are expressed in 50-70% of breast cancer tissue.The role of ERα as a prognostic marker in breast cancer has been well established as its expression negative correlated with tumor size and lymph node metastasis.ERβ is also a favorable prognostic predictor for breast cancer although it was less documented than ERα.MATERIALS AND METHODS:To explore whether ERa independently or their coexpression influences clinical outcomes in breast cancer, the correlation between the ERa with the clinicopathological features was analyzed in 84 patients.RESULTS: ERα expression negatively correlated with tumor stage (r=-0.246, p=0.028) and trended to be negatively correlated with lymph node status(r=-0.156,p=0.168) and tumor size(r=-0.246, p=0.099).Also, ERβ was negatively correlated with nodal status (r=-0.243,p=0.028).Finally, the coexpression of ERα and ERβ negatively correlated with nodal status (p=0.043, OR=0.194, 95% CI=0.040-0.953).CONCLUSION: Coexpression of ERs might serve as a good prognosis in breast cancer patients.
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