Nitrates and nitroglycerin (NG) are common medications used to dilate blood vessels, decrease blood pressure, improve circulation and control angina.Nitric oxide (NO) deficiency has been implicated in many pathological and physiological processes within the mammalian body (1).Administration of exogenous NO is a practical way to supplement NO, when body cannot generate adequate NO for its physiological functions (e.g., menopause).NO may also be involved with other cellular functions such as isoprenylation (geranylgeranylation) of the Rho GTPase that stimulates RhoPK (the functioning Rho-PK in turn inactivates something that would otherwise turn on the BMP-2/Cbfa1-Runx-2 cycle).New NO-releasing drugs that are capable of delivering NO to the blood stream or local tissues in a sustained, controlled, or episodic manner further increase opportunities.This has been achieved by attaching an organic nitrate component on to existing donor molecules with various spacers such as aliphatic or aromatic chain, with different degree of complexity.