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Cysteinyl cathepsins (Cats) have been implicated in the process of angiogenesis.we investigated the role of CatK in ischemia-induced neovascularization with a special focus on Notch1 activation in old mice.Serial laser Doppler blood-flow analysis revealed that the recovery of the ischemic/normal blood-flow ratio in CatK Deficient old mice remained impaired throughout the follow-up period.