评估谷氨酰胺对65岁以上初诊2型糖尿病患者的作用

来源 :2015中国老年医学和老年健康产业大会 | 被引量 : 0次 | 上传用户:xinxinxiangrong1
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  目的:综合评估谷氨酰胺对65岁以上初诊2型糖尿病患者的治疗作用方法:云南省第一人民医院老年病科共选取44例初诊的65岁以上2型糖尿病患者,随机分为治疗组(n=22)和对照组二组(n=22),对照组给予盐酸二甲双胍(0.75g/d)治疗,治疗组给予盐酸二甲双胍(0.75g/d)和谷氨酰胺(4.02g/d)综合治疗,分别在治疗前后,收集患者血清,全自动生化仪分析患者肝功能[天冬氨酸转氨酶(AST),谷丙转氨酶(ALT),总胆汁酸(TBA)和碱性磷酸酶(AKP)],肾功能[血清尿素氮(BUN),血肌酐(CREA),血尿酸(UA)和肌酐清除率(Ccr)],心肌功能[乳酸脱氢酶(LDH),肌酸激酶(CK),肌酸激酶-MB(CK-MB)和α羟丁酸脱氢酶(a-HBDH)],血脂[总胆固醇(TC),甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)]和血糖.采用试剂盒检测血清胰岛素、血清同型半胱氨酸含量、抗氧化能力[谷胱甘肽(GSH),过氧化氢酶(CAT),超氧化物歧化酶(SOD)和一氧化氮(NO)]以及炎性因子[白细胞介素1α(IL-1α),白细胞介素1β(IL-1β),白细胞介素6(IL-6)和肿瘤坏死因子(TNF-a)],比较分析治疗效果.
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