OBJECTIVE: The study aimed to identify potential biomarkers associated with Chinese Uygur Parkinsons disease (PD) with cognitive impairment (PD-CI) in peripheral monocytes.METHODS: We applied gene expression profiling to the study of peripheral monocytes from 3 Chinese Uygur patients with PD-CI and 3 healthy control subjects.Healthy control subjects were matched for age and gender with PD-CI subjects, RNA was extracted from the monocytes samples and the gene expressions were measured using the Illumina HumanHT-12 v4.0 Expression BeadChip, according to the screening criteria of Ratio≥2 and Ratio≤-2.At last, QuantiFast SYBR Green PCR (qRT-PCR) test was performed on samples collected from 31 PD-CI subjects and 35 controls to verify the microarray results.