Forkhead Box P3 (FoxP3) is thought to be a key transcription factor in regulatory T cells (Tregs), and recent data indicate it is expressed in several tumor cells.However, its precise role and function in gastric cancer (GC) is poorly understood.Here, we show that strong cytoplasmic staining of FoxP3 was observed in GC cells and nuclear staining in lymphocytes in 150 cases of gastric precancer and cancer.