【摘 要】
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Apomorphine (APO),a potent D1/D2 dopamine receptor agonist,is currently used as an antiparkinsonian drug.We have shown previously that APO stimulates synthe
【机 构】
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Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Shanghai, 20
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Apomorphine (APO),a potent D1/D2 dopamine receptor agonist,is currently used as an antiparkinsonian drug.We have shown previously that APO stimulates synthesis and release of multiple trophic factors,such as BDNF and GDNF,in both mesencephalic and striatal neurons,thereby effectively preventing dopaminergic neuron loss in vitro.The present study was designed to investigate the effects of APO on FGF-2 expression and regulation in astrocytes,and furthermore,to identify signaling mechanisms underlying these effects.
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