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5. Bidirectional Modulation of HIF-2 Activity through Chemical Ligands

Bidirectional Modulation of HIF-2 Activity through Chemical Ligands

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：liouwanji

【摘 要】

：

Hypoxia-inducible factor-2(HIF-2)is a heterodimeric transcription factor formed through the dimerization of an oxygensensitive subunit HIF-2α and a nucleus-locating subunit ARNT.Enhanced HIF-2 activit

【作 者】

：

Dalei Wu Xiaoyu Su Jingping Lu Sheng Li Becky L.Hood Stefan Vasile Nalini Potluri Xiaotong Diao Youngchang Kim Sepideh Khorasanizadeh Fraydoon Rastinejad 

【机 构】

：

Shandong University-Helmholtz Institute of Biotechnology,State Key Laboratory of Microbial Technolog

【出 处】

：

中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议

【发表日期】

：

2018年10期

【关键词】

：

Allosteric effect Crystal structure Antagonist Agonist Dimer interface Protein-p 

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论文部分内容阅读

　　Hypoxia-inducible factor-2(HIF-2)is a heterodimeric transcription factor formed through the dimerization of an oxygensensitive subunit HIF-2α and a nucleus-locating subunit ARNT.Enhanced HIF-2 activity drives a number of cancers,whereas reduced activity in the setting of chronic kidney disease causes anemia.

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