论文部分内容阅读
Pathological ocular angiogenesis is a major cause of blindness.Increased dietary intake of ω-3 long-chain polyunsaturated fatty acids(LCPUFAs)reduces retinal and choroidal neovascularization,but ω-3 LCPUFA metabolites of a major metabolizing pathway,cytochrome P450 oxidase(CYP)2J,promote ocular pathological angiogenesis.We hypothesized that inhibition of CYP2J activity will augment the protective effects of ω-3 LCPUFAs on neovascular eye diseases.