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Objective: To evaluate the utility of several tumor markers HE4,CA125,CA724 and CA19-9 as potential markers in patients diagnosed with endometrial cancer(EC).Methods: Blood samples from 105 patients with endometrial cancer(EC)and 87 healthy women were analyzed and serum values were measured for the following biomarkers: HE4,CA125,CA724 and CA19-9.Results: Serum HE4,CA125,CA724 and CA19-9 concentrations were significantly higher in the EC patients compared with healthy controls(p<0.001).