Epidermal growth factor receptor(EGFR)as a receptor tyrosine kinase stimulates downstream signaling to involve many cellular processes including cell proliferation.EGFR is localized on cell membrane to induce metastasis of many cancers including cancers in children,but it contains a nuclear localization signal(NLS)that allows the import of EGFR into the nucleus.The present study aims to define the evolution of nuclear EGFR(nEGFR)and the origin of EGFR in cancers.