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Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) activated up-and down-stream inflammatory immunity-mediated tumor development network was computed the biological processes and occurrence numbers of gene ontology (GO) in high expression (fold change ≥2) human hepatocellular carcinoma (HCC) compared with low expression no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) for finding new biomarkers of diagnosis and therapy in hepatocellular carcinoma.