Over the past few decades, there has been a substantial increase in tobacco smoking and obesity in many Asian countries.Obesity and tobacco smoking are major risk factors for many diseases, including cardiovascular disease, type 2 diabetes, and cancers of multiple sites.The overall impact of these two risk factors on mortality in many Asian countries remains unknown.As part of the Asia Cohort Consortium, we performed pooled analyses of data from approximately 1 million participants in~20 cohorts conducted in seven Asian countries/regions to quantify the risks of total and cause-specific mortality associated with tobacco smoking and body mass index (BMI), as a measure of body weight.