Natural Killer Cells Improve Generation of Bone Marrow-Derived Hepatocytes in Murine Liver Failure i

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户:hnxmyuandong
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Backgroud & aim: It has been well-recognized that bone marrow transplantation can rescue severe liver failure through the generation of bone marrow-derived hepatocytes (BMDHs), however, the mechanism for in vivo production of BMDHs remains obscure.Methods: Fumarylacetoacetate hydrolase (Fah) deficient mice were lethally irradiated and transplanted with bone marrow cells, followed by withdrawal of the drug 2-(2-nitro-4-trifluoro-methylbenzoyl)-1,3 cyclohexanedione (NTBC) to select for BMDHs.
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