Towards Defining Chromatin Dynamics at DNA Double-Strand Breaks

来源 :The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern | 被引量 : 0次 | 上传用户：christian1985

【摘要】

：

　　Chromatin modifications at DNA double-strand breaks (DSBs) play pivotal roles in coordinating DNA repair processes with other ongoing chromatin transaction

【作者】

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LiweiAN;JieChen;MichaelHuen;

【机构】

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The University of HongKong,Hongkong

【出处】

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The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern

【发表日期】

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2015年期

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　　Chromatin modifications at DNA double-strand breaks (DSBs) play pivotal roles in coordinating DNA repair processes with other ongoing chromatin transaction events,including DNA replication and transcription.However, exactly how this is dynamically regulated is not known.How do cells localize DNA repair machineries to DSBs? How are these DNA-modifying activities buffered from otherwise intact chromosomal loci to prevent unscheduled chromosomal rearrangements?

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Towards Defining Chromatin Dynamics at DNA Double-Strand Breaks

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