Interaction between dopaminergic and cholinergic transmission in the nucleus accumben mediates the h

来源 :中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the | 被引量 : 0次 | 上传用户：shuanghu1000

【摘要】

：

【作者】

：

Wenhua ZHOU Hui-Fen LIU Sui-En TANG Miao-Jun LAI Hua-Qiang ZHU Fu-Qiang ZHANG

【机构】

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Laboratory of Behavioral Neuroscience, Ningbo Addiction Research and Treatment Center, School of Med

【出处】

：

中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the

【发表日期】

：

2007年12期

【关键词】

：

Nucleus accumben acetylcholine neuroadaptation heroin conditioning

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　　The mesolimbic dopamine system projects from VTA to the nucles accumbens (NAc) and is a key neural substrate regulating drug reinforcment.Our previous experiment showed that the enhacement of acetylcholine in NAc blocks the heroin seeking induced by conditioned cues.The present study was to observe the activation patterns of NAc neurons marked by FosB during the instatement induced by condtioned cues after heroin withdrawal.The rats were self-administered heroin infusion under escalating FR 1-5 reinforcement schedule for two weeks.

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Interaction between dopaminergic and cholinergic transmission in the nucleus accumben mediates the h

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