【摘 要】
：
Since the discovery of dopamine as a chemical neurotransmitter in the brain, many human neurological disorders have been linked to the malfunction of this important neural system.For example, Parkinso
【机 构】
：
Deaprtment of Biopharmaceutical Sciences, Programs in Human Genetics and Biological Sciences Univers
【出 处】
：
2005 WHTS3rd Annual Congress of International Drug Discovery
论文部分内容阅读
Since the discovery of dopamine as a chemical neurotransmitter in the brain, many human neurological disorders have been linked to the malfunction of this important neural system.For example, Parkinsons disease is caused by the selective degeneration of dopamine neurons in the substantia nigra, and dopamine system is strongly implicated in the development of drug and alcohol addiction.The mechanisms underlying dopamine neuron development, regeneration,degeneration, and function are not well understood, and as a consequence, effective treatments for the related human disorders are largely lacking.In this talk, we will discuss our use of a simple vertebrate model system, the zebrafish Danio rerio, to study mechanisms underlying dopamine neuron development, degeneration, and to develop cellular and behavioral assays for functional gene discovery and small molecule screening.
其他文献
Herbal drug mixtures usually contain hundreds of compounds.Some compounds exist in high concentration as major components and others exist in very low concentration as minor components.In most situati
For more than 50 years, physicians worldwide considered antibiotics as rapid and effective management of many of the most common infection of the most common conditions.According to data supplied by t
The purpose of this research is to design a mosaic protein which could be used to cure cephalophyma and cerebral edema during acute cerebral stroke.The foundation of designing this mosaic protein (TNH
Proteomics, the analysis of expressed proteins, is becoming rapidly important in the postgenomic era.A primary aim of clinical proteomics is the identification of biomarkers for diagnosis and therapeu
The anthrax lethal factor (LF),a Zn-dependent endopeptidase,has a major role in the development and virulence of anthrax,an infectious disease caused by the toxigenic bacterium Bacillus anthracis. Con
Basic fibroblast growth factor (bFGF) and its application in accelerating acute wound healing.In general, acute wound healing process is convenient to divide the overall into three overlapping phases:
Microtubule-binding protein Tau is critical for neuronal function.Expression and function of human tau gene are under complex regulation by alternative splicing.Exclusion or inclusion of exon 10 leads
There is no cure for AIDS at this time, although, highly active antiretroviral therapy (HAART) has greatly improved the outcome of HIV/AIDS, it is limited by side effects, viral drug-resistant, and th
The identification of tumor-specific cell surface antigens is a critical step towards the development of targeted cancer therapeutics.The epitope space at the tumor cell surface is highly complex, com
High-throughput chemical screens can be performed on intact zebrafish, making it possible to assess the effects of small molecules rapidly, inexpensively, and on a miniaturized scale.By combining the