【摘 要】
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3-amino allylic alcohols are versatile synthetic intermediates and could be conveniently converted to many useful organic compounds by known methods.Direct amination of carbon-hydrogen bonds is an ide
【机 构】
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Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry,School o
【出 处】
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第五届岭南有机化学论坛暨华南理工大学-兰州大学有机化学双边论坛
论文部分内容阅读
3-amino allylic alcohols are versatile synthetic intermediates and could be conveniently converted to many useful organic compounds by known methods.Direct amination of carbon-hydrogen bonds is an ideal way to construct nitrogen-containing compounds because of atom economy.An efficient route to prepare 3-amino allylic alcohols in excellent regio-and stereoselectivity in the presence of bases by orangoselenium catalysis has been developed.In the absence of bases α,β-unsaturated aldehydes were formed in up to 97％yield.Control experiments reveal that the hydroxy group is crucial for the direct amination.(Scheme 1).
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