【摘 要】
：
Objectives: To examine the expression of hypoxia inducible factor-1α (HIF-1 α), vascular endothelial growth factor (VEGF), aggrecanase-1 (ADAMTS-4), and tissue inhibitor of metalloproteinase-3 (TIMP-3
【机 构】
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Department of Oral and Maxillofacial Surgery,College of Stomatology,Guangxi Medical university,Nanni
【出 处】
：
11th Asian Congress on Oeal and Maxillofacial Surgery(第十一届亚洲
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Objectives: To examine the expression of hypoxia inducible factor-1α (HIF-1 α), vascular endothelial growth factor (VEGF), aggrecanase-1 (ADAMTS-4), and tissue inhibitor of metalloproteinase-3 (TIMP-3) in rat mandibular condylar chondrocytes under cobalt dichloride (CoC12)-induced hypoxic conditions and explore the mechanism of pathogenesis of TMJ associated diseases.Methods: CoC12 was used to mimic a hypoxic microenvironment by chemically inducing hypoxia.Chondrocytes, which were obtained from the mandibular condyles of 3-week-old female Sprague-Dawley rats were treated with 125 μmol/L CoC12 for 48 h.The HIF-1α, VEGF, ADAMTS-4, and TIMP-3 mRNA levels in chondrocytes were detected using a semi-quantitative polymerase chain reaction (PCR) at 12, 24, and 48 h after the initiation of hypoxia and normoxia conditions.A univariate variance analysis (pairwise LSD-t test) was performed between different groups using a SPSS 13.0 software package.
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