【摘 要】
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SL4, a chalcone-based compound, exhibits clearly inhibitory effects on HIF-1 and has been shown to effectively suppress tumor invasion and angiogenesis in vitro and in vivo.Here, we demonstrate that S
【机 构】
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Department of Pharmacology,Shenyang Pharmaceutical University,103 Wenhua Road,110016 Shenyang,PR Chi
【出 处】
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2015医学前沿论坛暨第十四届全国肿瘤药理与化疗学术会议
论文部分内容阅读
SL4, a chalcone-based compound, exhibits clearly inhibitory effects on HIF-1 and has been shown to effectively suppress tumor invasion and angiogenesis in vitro and in vivo.Here, we demonstrate that SI4 selectively kills cancer cells through inducing apoptosis.The in vitro study indicated that SL4 significantly inhibited the growth of human cancer cell lines but exhibited lower cytotoxicity against normal cells.Flow cytometry and western blot results showed that SL4 effectively induced apoptosis of Hep3B and MDA-MB-435 cells through activating procaspase-8,-9,-3 and down-regulating the expression levels of XIAP, but couldnt affect the HIF-1 apoptosis-related targets, Survivin and Bcl-xl.
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