【摘 要】
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Magnetic nanoparticles(NPs),which possess controlled size,shape and magnetic moments,have been applied as multifunctional probes in biomedical field,including MRI,drug delivery and magnetic hypertherm
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Magnetic nanoparticles(NPs),which possess controlled size,shape and magnetic moments,have been applied as multifunctional probes in biomedical field,including MRI,drug delivery and magnetic hyperthermia,by enhancement of contrast in magnetic resonance imaging(MRI)and emote manipulation.In this talk,we will talk about Hagg iron carbide(Fe5C2)magnetic NPs for bimodal tumor imaging and therapy(Scheme).[1-4] Interestingly,due to the presence of carbon layers of NPs,with high absorption in near-infrared(NIR)optical region,Fe5C2 NPs can be used for photoacoustic tomography(PAT)and photothermal therapy(PTT).The probe exhibits high saturation magnetization,r2 relaxivity and temperature increasing after exposure to NIR.The conjugation of Herceptin enabled the targeting to Her2-overexpressed cells(SK-OV-3 cells).
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