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Angiogenesis and rapid-proliferation of cancer cells are two of the most common characteristics of malignant tumors,which make it practical to develop more effective and universal drug delivery systems.In this study,we have designed and synthesized different functionalized selenium nanosystem to realize the dual therapy of tumor growth and angiogenesis.This dual-therapeutic nanosystem selectively inhibits cancer cell growth and simultaneously disrupts tumor neovasculature,thus achieving satisfactory anticancer efficacy in vitro and in vivo.Furthermore,the nanosystem triggers intracellular ROS overproduction in both cancer and human umbilical vein endothelial cells,which activates various downstream signaling pathways,leading to cell cycle arrest and cell apoptosis.Collectively,as an ideal nanodrug delivery system,this nanosytem demonstrates several advantages,including(1)dual therapy of tumor neovasculature and tumor cells,(2)high selectivity between cancer and normal cells,clear elucidation of the anticancer and antiangiogenic action mechanisms,(3)prolonged circulation and(4)no toxic side effects at effective dose.Therefore,this study may provide an approach for rational design of the next-generation nanodrug delivery system.