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  5. GRP151 demethylation and increased interaction with STAT3 contribute to the pathogenesis of neuropat

GRP151 demethylation and increased interaction with STAT3 contribute to the pathogenesis of neuropat

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：timhero
【摘 要】
：
G protein-coupled receptors(GPCRs)play important roles in the development and maintenance of chronic pain.Recent studies revealed that DNA methylation regulates gene transcription through dominating t
【作 者】
：
Wen-Wen Zhang Tian Yang Bao-Chun Jiang Yong-Jing Gao 
【机 构】
：
Pain Research Laboratory,Institute of Nautical Medicine,Jiangsu Key Laboratory of Inflammation and M
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
【关键词】
：
GPR151 neuropathic pain DNA methylation STAT3 
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　　G protein-coupled receptors(GPCRs)play important roles in the development and maintenance of chronic pain.Recent studies revealed that DNA methylation regulates gene transcription through dominating the binding of transcription factors.Meanwhile,signal transducer and activator of transcription 3(Stat3)has been proved to modulate nociceptive transmission by regulating gene transcription.
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