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  5. A Novel Unimolecular GLP-1/GIP/Gcg Triagonist Improves Cognitive Function and Hippocampal Synaptic P

A Novel Unimolecular GLP-1/GIP/Gcg Triagonist Improves Cognitive Function and Hippocampal Synaptic P

来源 :2016年国际生理学学术大会 | 被引量 : 0次 | 上传用户：waugh9071
【摘 要】
：
Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimers disease (AD). Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have been shown to have neuroprotec
【作 者】
：
Tian LI Juanjuan JIAO Hui SHI Li YUAN Jun ZHANG Yufei HAN Xuefan DONG Xuesong QU Jinshun QI 
【机 构】
：
Department of Neurobiology,Shanxi Medical University,Taiyuan,Shanxi 030001,China
【出 处】
：
2016年国际生理学学术大会
【发表日期】
：
2016年6期
【关键词】
：
GLP-1/GIP/Gcg triagonist 3×Tg-AD mice spatial memory long-term potentiation mEPS 
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　　Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimers disease (AD). Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have been shown to have neuroprotective properties by binding to their respective receptors in the brain. However, the native GLP-1 and GIP can be rapidly degraded by the enzyme dipeptidyl peptidase Ⅳ (DPP-Ⅳ).
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