Zinc &alpha-2 glycoprotein (ZAG) has molecular weight 39 kDa and it is present in human body fluids such as blood plasma,seminal plasma,saliva,sweat and cerebrospinal fluid.It is induced by glucocorticoids and androgens in breast cancer cell lines indicating its role in the progression of mammary diseases including breast cancer..It is also implicated in stimulation of lipolysis in adipocytes,activation of GTP dependent adenylate cyclase that leads to the activation of multiple cellular pathways,down regulation of tumor proliferation,ribonuclease activity as well as a carrier protein.