叶酸缺乏致Gcm1高效激活Wnt/β-catenin信号通路促进脊椎动物神经发育

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户:yy080408
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  Wnt/β-catenin信号通路在早期神经发育中起主要作用。当其紊乱会导致神经前-后轴发育缺陷引发神经管闭合缺陷(NTDs)。叶酸代谢的变化可能参与由转录因子驱动的早期胚胎命运决定。本研究发现神经管缺陷(NTDs)的低叶酸标本中,绒毛膜特异性转录因子Gcm1在标本脑组织中表达上调,并与β-catenin蛋白相互结合。
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