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Genes involved in proliferation and apoptosis are clearly important for the occurrence of mature spermatogenesis.Herein, we provide compelling evidence for the expression and functional role of Ras-related protein 1 (Rapl), a member of the Ras superfamily, in the mouse testis.Quantitative analysis revealed that Rapl expression gradually increased in the testis from 5 days postnatally, with maximum levels in adult specimens.