Generally speaking, linear conpolymers whose stability increased accompany with the adding of molecular weight, has hindered further adhibition of polymeric micelles due to poor ability in the field of nano-based drug delivery system (DDS) and targeting administration domain.However, star-shaped polymers with the advantages of smaller diffusion coefficient, lower solution viscosity and smaller hydrodynamic radius qualified themselves with strong anti-dilution property, enabling a new development of polymeric micelles.In this study, a new kind of stable and bio-compatible nano-carrier based on star-shaped diblock polymeric micelles were designed and investigated.With reversible addition-fragmentation chain transfer (RAFT) method, the amphiphilic diblock copolymers,comprised of beta-cyclodextrins core segments and poly (acrylic acid-co-methyl methacrylate)-b-poly (N-vinyl pyrrolidone) arms were synthesized, which were different in molecular weight (β-CD-[P(AA-co-MMA)-b-PVP]4, brief for β-CD-P4).Benefiting from its excellent biocompatibility and modifiable property, β-cyclodextrin was employed as the core part of this four-armed polymer.Meanwhile, among seven secondary hydroxyl groups of the smaller opening of β-cyclodextrin, four hydroxyls were decorated with hydrophobic and hydrophilic substituents to construct the four arms of β-CD-P4.Micellization behaviors of this star-shaped polymer (β-CD-P4) were detected by critical micelle concentration (CMC), drug loading efficiency (DL) and in vitro drug release indicators.Those Results showed that β-CD-P4 were capable to self-assemble under a very low concentration of 5.852× 10-3mg/1.And with a high DL of 12.7% and 66.4nm mean particle size, this star polymer exhibited a sustainable and controlled-release property at physiological pH condition.In vivo tissue distribution demonstrated that compared with vinpocetine (VP) injection,VP-loaded star-shaped polymeric micelles (VP/β-CD-P4 micelles) prepared by a solvent evaporation method showed an apparent lung targeting character, whose targeting efficiency (Te) was 8.98 times higher than VP injection.Herein, those results making β-CD-P4 an excellent candidate for application in the fields of nanoparticle drug delivery system and pulmonary targeting administration.