【摘 要】
：
背景:由于耐药性以及无法中和内毒素,被革兰氏阴性菌感染的患者,传统的抗生素对其疗效不佳.将杀菌/渗透增强蛋白和IgG1Fc片段嵌和基因(BPI700-Fcγ1700)导入BALBc小鼠,观察对最小致死量大肠杆菌内毒素攻击的抵抗作用,以及结肠上皮电阻和离子转运的改变,探讨抗感染基因治疗在临床感染高危人群中应用的可能性.
【机 构】
：
首都医科大学基础医学院生理学与病理生理学系,北京100069 首都医科大学基础医学院免疫系,北京1
【出 处】
：
中国生理学会消化内分泌生殖代谢生理专业委员会2014年消化内分泌生殖代谢学术会议
论文部分内容阅读
背景:由于耐药性以及无法中和内毒素,被革兰氏阴性菌感染的患者,传统的抗生素对其疗效不佳.将杀菌/渗透增强蛋白和IgG1Fc片段嵌和基因(BPI700-Fcγ1700)导入BALBc小鼠,观察对最小致死量大肠杆菌内毒素攻击的抵抗作用,以及结肠上皮电阻和离子转运的改变,探讨抗感染基因治疗在临床感染高危人群中应用的可能性.
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