【摘 要】
：
Exposure to a moderate and high dose of ionizing radiation (IR) induces not only acute hematopoietic radiation syndrome (ARS) but also long-term (LT) bone marrow (BM) injury.
【机 构】
：
Institute of Radiation Medicine,Peking Union Medical College & Chinese Academy of Medical Science;Ti
论文部分内容阅读
Exposure to a moderate and high dose of ionizing radiation (IR) induces not only acute hematopoietic radiation syndrome (ARS) but also long-term (LT) bone marrow (BM) injury.
其他文献
Background Acute myeloid leukemia (AML)is generally regarded as a disorder of stem cells,known as leukemic initiating cells (LICs),which initiate the disease and contribute to relapses.
Most clinical applications of human mesenchymal stromal cells (MSCs) for cell therapy,tissue engineering,regenerative medicine,and treatment of immune diseases require ex vivo expansion.
BACKGROUND:In acute myeloid leukemia (AML),the leukemia initiating cells (LICs) or leukemia stem cells (LSCs) is found within the CD34+CD38-cell compartment.The LICs subpopulation survives chemotherap
Chronic myelomonocytic leukemia (CMML) is a hematologic disease currently classified in the category of myelodysplastic syndromes / myeloproliferative neoplasm (MDS/MPN).CMML is a clonal disorder in t
Mesenchymal stem cells from multiple myeloma patients (MM-hMSCs) possess abnormal characteristics compared to their counterparts from normal donors (ND-hMSCs),exhibited by an enhanced spontaneous and
Acute graft-versus-host disease (aGvHD),is the most common complication of allogeneic hematopoietic stem cell transplantation (HSCT),which is often accompanied by impaired hematopoietic reconstitution
Na+/H+ exchanger 1 (NHE1) is an important regulator of intracellular pH (pHi).High pHi is required for cell proliferation and differentiation.Our previous study has proven that the pHi of mesenchymal
ZFX (Zinc finger protein,X-linked) is a key regulator of both embryonic stem cells (ESCs) and hematopoietic stem cells (HSCs).A recent report has demonstrated that Zfx is required for Notch intracellu
Trithorax group proteins methylate lysine 4 of histone3 (H3K4) at active gene promoters.MLL5 protein,a member of the Trithorax protein family,has been implicated in the control of the cell cycle progr
Our recent study identified a nonsense mutation of La-related protein 4B (LARP4B) from whole genome sequencing of a 3-year-old female monozygotic twin pair discordant for MLL-associated acute myeloid