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Schizophrenia is characterized by disturbances of perception, emotion, social functioning and cognition.Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributing factors.Increasing evidence supports an importantrole of oligodendrocyte (OL) in the pathogenesis of schizophrenia.Genome-wide gene expression analyses clearly haveshowndysregulation of myelination-related genes.