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MicroRNAs (miRNAs) have emerged as potent therapeutic agents for numerous diseases due to their ability to specifically silence targeted genes efficiently.However,the clinical success of miRNA therapeutics is still hindered by their delivery systems.Exosomes are natural membrane vesicles within nanometer-size range (30-100 nm) and secreted by almost all types of cells.Here we examined the ability of exosome as miRNA delivery vehicle in vitro.