Boronic Acid-Rich Protein and polysaccharide Nanoparticles for Drug Delivery

来源 :中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户:mujun246
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  Over past three decades,the approaches to targeting nanomaterials in vivo have been intensely explored.However,the level of antitumor agent in tumor sites is still low.Thus,the development of new drug delivery systems which can effectively target drug to tumor and prevent drug rapid washout from tumor is highly desirable for the communities of materials science,chemistry and medicine.On the other hand,after extravasation from tumor vessels,nanocarriers are mainly limited to the very adjacent regions due to the high interstitial fluid pressure,dense interstitial matrix and abnormal vasculature of tumors,leaving large tumor areas untouched by the carried therapeutic agents and limiting greatly their therapeutic effects.It has been demonstrated that the tumor penetration ability of nanomaterials increases with the decrease of their size.Accordingly,the low-nanometer size of polymeric nanocarriers most likely imparts favorable penetration ability.
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