Surface enhanced Raman scattering(SERS)is a highly sensitive and noninvasive vibrational spectroscopic technique,which can rapidly provide intrinsic fingerprint information of analytes or bioanalytes and also be used for varieties of molecular/cellular sensing or imaging.1,2 Wherein,these solid-state electrospun SERS substrates exhibit a sensitivity to target molecules and the more uniformity of AgNPs on electrospun nanofibers will lead to reproducible and stable SERS signals.