Congenital cataract is the leading cause of childhood blindness worldwide and about half of the cases are caused by genetic alternations.In this study, we identified a three-generation Chinese family
Candida albicans is an opportunistic human pathogen.Emergence of drug resistant strains makes it necessary to develop new anti-Candida drugs.Vps4 is an AAA ATPase critical for the function of the ESCR
Congenital cataract is the leading cause of childhood blindness worldwide.Investigations of the effects of inherited mutations on protein structure and function not only help us to understand the mole
The mTOR (mammalian target of rapamycin) signaling pathway plays a major role in cell growth and metabolism in eukaryotes.In metazoans, the mTOR kinase exists in at least two distinct complexes, mTORC
Candida albicans is an opportunist human pathogen.Its invasion into human tissue depends on its hyphal growth.Research shows many external signals triggers the process.One of this is alkaline pH that
Osteopontin (OPN) is a multifunctional phosphorylated glycoprotein and it is involved in a broad range of functions in both physiological and pathological processes.
Alzheimer disease has been defined as Type 3 Diabetes due to their shared metabolic profiles.As well as our previously research results of Alzheimers disease and othe neurodegenerative diseases, syste
The essential bacterial protein FtsZ is a guanosine triphosphatase that self-assembles into a structure at the division site termed the "Z ring".During cytokinesis, the Z ring exerts a constrictive fo
One key question in signal transduction is how the signal is relayed from the outer leaflet of a cellular membrane to the inner leaflet.Using a simulation model, a mechanism for the mediation of signa