In the synthesis of N-Boc-5-methyl-1H-pyrrol-2-ylboronic acid(4),the pyrrole was used as starting material,through Vilsmere reaction,LiAlH4 reduction,protection of BOC anhydride,treatment with n-butyl lithium,subsequent reaction with B(OMe)3 and final hydrolysis using KHSO4.The target product was identified by 1HNMR and HR-ESI-MS.Reaction condition of key reactions was optimized in order to give a high yield and facile synthetic route.