【摘 要】
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Three new targeted drugs developed in China In recent years.The first one rhEndostatin (endostar)which first presented in ASCO meeting in 2005 (Proc ASCO 20
【机 构】
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NationalGCPCenterforAnticancerAgents,CancerHospital/Institute,CAMS&PUMCChina
论文部分内容阅读
Three new targeted drugs developed in China In recent years.The first one rhEndostatin (endostar)which first presented in ASCO meeting in 2005 (Proc ASCO 2005, Abstract 7138) and approved by SFDA in 2006.In a randomized double blind Phase III trial, 493 histology or cytology confirmed stage ⅢB and Ⅳ NSCLC patients, were entered either Arm A: NP plus endostar (n=326; vinorelbine 25mg/m2 on day 1 and day5, cisplatin 30mg/m2 on days 2 to 4, endostar 7.5 mg/m2 on days 1 to 14) or Arm B: NP plus placebo (n=167; vinorelbine 25mg/m2 on day 1 and day5, cisplatin 30mg/m2 on days 2 to 4, 0.9% sodium-chloride 3.75 ml on days 1 to 14) every 3 weeks for 2-6 cycles,according to the response after the second cycles, i.e.CR, PR, SD continue to receive treatment;while PD stop treatment.
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