【摘 要】
：
Elevated circulating saturated fatty acids concentration is commonly associated with poorly controlled diabetes.The highly prevalent free fatty acid (FFA),
【机 构】
：
FuJianProvincialKeyLaboratoryofTransplantBiologyFuzhouGeneralHospitalXiamenUniversityChina
【出 处】
：
2013第三届内分泌与代谢大会暨2013第二届糖尿病大会
论文部分内容阅读
Elevated circulating saturated fatty acids concentration is commonly associated with poorly controlled diabetes.The highly prevalent free fatty acid (FFA), palmitate, could induce apoptosis in various cell types, but little is known about its effects on human mesenchymal stem cells (MSCs).Here, we report that prolonged exposure to palmitate induces human bone marrow derived MSCs (hBMMSCs) and umbilical cord-derived MSC (hUC-MSCs) apoptosis.We investigated the role of endoplasmic reticulum (ER) stress, which is known to promote cells apoptosis.Palmitate activated XBP 1 splicing, elF2α phosphorylation, and CHOP, ATF4, BiP and GRP94 transcription in hBMMSCs.
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