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To investigate the effect of Lipoic acid on the release of cytokines (TNF-α, IL-1 β, IL-6 and IL-10) and the expression of chemokines (CCL2, CCL3, CCL5 and CCL20 mRNA) in cultured astrocytes stimulated by lipopolysaccharide.Primary cultured astrocytes were stimulated with lipopolysaccharides (LPS, lμg/ml), and treated with Lipoic acid (LA, 100μg/mL).